Intramuscular Immunoglobulin for Measles Postexposure Prophylaxis

AbstractIntramuscular immunoglobulin (IMIG) administered at a dose of 0.5 ml/kg is an option for prophylaxis in infants after exposure to measles. The weight-based dosing volumes require multiple or large-volume injections; however, no clear administration guidelines exist. In 2025, the Utah Department of Health and Human Services (DHHS) assisted with coordination of IMIG administration after an exposure event at a pediatric clinic. Utah DHHS worked with the local health department and health care facility to develop a plan for administration that has been used in subsequent exposure events in Utah.