retained improved phototoxicity under hypoxic conditions, suggesting partial preservation of PDT efficacy when oxygen availability is limited. Zebrafish biodistribution studies revealed limited blood-brain barrier penetration, supporting potential application in extracranial neuroblastoma. This work establishes a metal-free strategy for integrating controlled gasotransmitter release with PDT and provides a molecular framework for next-generation light-activated combination phototherapeutics.
Kwangmettatam et al. (Wed,) studied this question.