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Reveals improved differentiation of endothelial cells from induced pluripotent stem cells, indicating potential therapeutic applications.
endothelial cells in the cell population. Furthermore, quantitative RT-PCR showed that the addition of iSN04 increased the gene expression of vascular endothelial cell markers such as von Willebrand factor. Analysis of cells on Day 3 after the addition of iSN04 revealed an increase in the expression of Brachyury-T, a marker of the mesoderm. These results suggest that iSN04 may improve the differentiation efficiency of cells, such as vascular endothelial cells, into other mesodermal cells by promoting mesoderm differentiation.
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Yamaguchi-Shibano et al. (2026) studied this question.
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