Key result
Insulin-glucose treatment during verapamil toxicity significantly increased ventricular elasticity at end-systole compared to saline controls (34 vs 15 mm Hg/mm; p<0.05).
Why the study?
Does insulin-glucose treatment improve myocardial contractile function in a canine model of verapamil toxicity?
RCT (n=18)
Randomized
Does insulin-glucose treatment improve myocardial contractile function in a canine model of verapamil toxicity?
Absolute Event Rate: 34% vs 15%
p-value: p=<0.05
In a canine model of verapamil toxicity, insulin-glucose treatment improved myocardial contractile function despite verapamil-induced myocardial insulin resistance.
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May improve contractility in verapamil toxicity models; leaves open translation to clinical overdose management.
Kline et al. (1996) conducted an RCT in Verapamil toxicity (n=18). Insulin-glucose vs. Saline was evaluated on Ventricular elasticity at end-systole (Ees) (p=<0.05). Insulin-glucose treatment during verapamil toxicity significantly increased ventricular elasticity at end-systole compared to saline controls (34 vs 15 mm Hg/mm; p<0.05).
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