“Novel Approaches for Polymer‐Based Ocular Delivery for BCS Class II Drugs for Sustained Ocular Delivery”

Biopharmaceutics Classification System (BCS) Class II drugs possess low solubility, which presents a significant challenge in ocular drug delivery by limiting the therapeutic efficacy and bioavailability of the drug. This review focuses on the application of polymer‐based approaches to enhance the solubility and delivery of these drugs to ocular tissues. Different drug delivery systems, such as polymeric nanoparticles, hydrogels, and micelles, are discussed with an emphasis on their roles in enhancing solubility, stability, and sustained drug release. The interaction between polymers and ocular tissues is analyzed to ensure safety and efficacy. Advancements in polymer engineering and formulation strategies are highlighted, showcasing their potential to overcome the complex anatomical and physiological barriers of the eye. This article highlights the transformative potential of polymer‐based technologies in addressing solubility challenges, enhancing drug retention, and enabling sustained and targeted ocular drug delivery.