Engineering increased transglycosylation in rutinosidase by altering the side tunnel, suggesting a new structural approach.
, which has a side groove instead of a side tunnel. The trans-rutinosylation abilities of the enzymes were tested using a diverse library of acceptors. This work expands the structure-function understanding of fungal rutinosidases and underlies the hypothesis that the engineering of the side tunnel can increase the transglycosylation-to-hydrolysis ratio.
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Petrásková et al. (2026) studied this question.
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