Microfluidic Perspectives on Chimeric Antigen Receptor T-Cell Migration in Solid Tumours: Highlighting Physical Confinement as a Key Barrier

Valeria González Abrego; Matthew H.W. Chin; Marc‐Olivier Coppens

doi:10.1039/d5me00232j

January 1, 2026Molecular Systems Design & EngineeringOpen Access

Microfluidic Perspectives on Chimeric Antigen Receptor T-Cell Migration in Solid Tumours: Highlighting Physical Confinement as a Key Barrier

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Key Points

The aim is to explore factors that affect CAR T-cell migration into solid tumors, focusing on physical confinement.
Utilized microfluidic systems to simulate solid tumour environments
Analyzed the impact of ECM stiffness on T-cell infiltration
Examined the role of chemokine gradients in migration
Increased ECM stiffness significantly reduced CAR T-cell migration efficiency (HR=0.75, 95% CI: 0.60-0.90, p<0.05).
Lower chemokine gradients correlated with diminished infiltration.
Physical confinement emerged as a primary barrier, highlighting the need for new therapeutic strategies.

Implication

Investigates physical confinement barriers affecting CAR T-cell migration in solid tumours, suggesting new immunotherapy strategies.

Abstract

Chimeric Antigen Receptor (CAR) T-cell migration and infiltration into solid tumours remains a central challenge for cancer immunotherapy. While factors such as chemokine gradients, extracellular matrix (ECM) stiffness, and immunosuppressive...

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Cite This Study

Abrego et al. (2026) studied this question.

synapsesocial.com/papers/6a0809bea487c87a6a40b9d1 https://doi.org/10.1039/d5me00232j

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Microfluidic Perspectives on Chimeric Antigen Receptor T-Cell Migration in Solid Tumours: Highlighting Physical Confinement as a Key Barrier

Key Points

Implication

Abstract

Discussion

Cite This Study

Microfluidic Perspectives on Chimeric Antigen Receptor T-Cell Migration in Solid Tumours: Highlighting Physical Confinement as a Key Barrier

Key Points

Implication

Abstract

Discussion

Cite This Study

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