Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

Tamer El Malah; Ahmed A. El-Rashedy

doi:10.1039/d6ra01413e

January 1, 2026RSC AdvancesOpen Access

Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

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Key Points

This research aims to synthesize and evaluate novel phenyl triazole-pyridylpiperazine derivatives for their anticancer effects.
Synthesis of phenyl triazole-pyridylpiperazine derivatives
Testing against cancer cells
Molecular modeling and computational studies to predict activity
Compounds 15 and 18 showed potent anticancer activity comparable to doxorubicin
Favorable ADME profiles noted for the compounds
Stable binding to EGFR was observed

Implication

Demonstrates targeted anticancer activity in cancer cells, suggesting novel treatment options.

Abstract

Novel phenyl triazole-pyridylpiperazine derivatives were synthesized & tested against cancer cells. Compounds 15 & 18 showed potent anticancer activity comparable to doxorubicin, with favorable ADME profiles & stable EGFR binding.

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Cite This Study

Malah et al. (2026) studied this question.

synapsesocial.com/papers/6a0809d7a487c87a6a40bbb8 https://doi.org/10.1039/d6ra01413e

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Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

Key Points

Implication

Abstract

Discussion

Cite This Study

Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

Key Points

Implication

Abstract

Discussion

Cite This Study

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