Novel ABO*B allele (c. 701C >T) on ABO*B.01 in a Chinese B(A) phenotype individual

May 14, 2026Transfusion

Novel ABOB allele (c. 701C >T) on ABOB.01 in a Chinese B(A) phenotype individual

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To identify and analyze a novel ABO*B allele in an individual with a unique B(A) phenotype.
Schematic diagrams of wild-type and mutant structures of the B119 protein were created.
Ramachandran plot analysis assessed stereochemical quality of the predicted protein models.
Structural comparison of wild-type and mutant alleles analyzed the effects of specific mutations.
Mutation analysis showed a novel c.701C>T change in the ABO*B allele.
Ramachandran plots demonstrated favorable stereochemical quality in both wild-type and mutant models.
Comparative analysis highlighted structural alterations at critical sites that may affect protein function.

Case reveals a novel ABO*B allele affecting protein structure in a unique B(A) phenotype individual, indicating genetic diversity in blood types.

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Shi et al. (2026) studied this question.

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