Lactate-Sensitive Nanomachines for Enzyme-Controlled Drug Delivery in Cancer Therapy

Marta González‐Jiménez; Teresa Moreno; Beatriz Mayol; Esther García Díez; Soraya Salido; Alfredo Sánchez; Narcisa Martínez Quiles; Paloma Martínez‐Ruiz; Diana Vilela; Reynaldo Villalonga

doi:10.1039/d6tb00119j

January 1, 2026Journal of Materials Chemistry B

Lactate-Sensitive Nanomachines for Enzyme-Controlled Drug Delivery in Cancer Therapy

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Key Points

The aim is to develop a novel enzyme-driven nanomachine for targeted drug delivery in cancer treatment.
Preparing mesoporous silica nanoparticles with a cyclodextrin-lactate oxidase (CD-LOx) complex for drug delivery.
Utilizing enzyme sensitivity to regulate the release of drug cargo in response to lactate levels.
Demonstrated effective control of drug release in vitro under varying lactate concentrations.
Achieved enhanced therapeutic effects in cancer cells due to targeted delivery.

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Implication

Novel enzyme-powered nanomachines enable controlled drug delivery in cancer therapy, suggesting improved treatment outcomes.

Abstract

Here, we report the preparation of a novel enzyme-powered nanomachine for drug delivery system based on mesoporous silica nanoparticles capped with a cyclodextrin-lactate oxidase (CD-LOx) complex, which enables controlled cargo...

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González‐Jiménez et al. (2026) studied this question.

synapsesocial.com/papers/6a0809f1a487c87a6a40bd59 https://doi.org/10.1039/d6tb00119j

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Lactate-Sensitive Nanomachines for Enzyme-Controlled Drug Delivery in Cancer Therapy

Key Points

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Discussion

Cite This Study

Lactate-Sensitive Nanomachines for Enzyme-Controlled Drug Delivery in Cancer Therapy

Key Points

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Implication

Abstract

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