Elevated uric acid-to-HDL cholesterol ratio was independently associated with coronary slow flow (OR 1.20 per 0.01-unit increase; 95% CI 1.09-1.31; P < .001).
Cross-Sectional (n=218)
Is the uric acid-to-high-density lipoprotein cholesterol ratio (UHR) associated with coronary slow flow in patients with normal or near-normal coronary arteries?
Elevated uric acid-to-HDL cholesterol ratio is independently associated with coronary slow flow, suggesting its potential as a readily available biomarker for coronary microvascular dysfunction.
Effect estimate: OR 1.20 per 0.01-unit increase (95% CI 1.09-1.31)
Absolute Event Rate: 0.13% vs 0.09%
p-value: p=< .001
BACKGROUND: Coronary slow flow (CSF) is an angiographic finding characterized by delayed distal vessel opacification despite normal epicardial coronary arteries. Its pathophysiology is multifactorial and involves microvascular dysfunction, endothelial impairment, and chronic inflammation. The uric acid-to-high-density lipoprotein (HDL) cholesterol ratio (UHR) has recently emerged as a novel composite biomarker reflecting both pro-oxidant and anti-inflammatory balance. This study aimed to evaluate the relationship between UHR and CSF. METHODS: In this retrospective cross-sectional study, 218 patients with normal or near-normal coronary arteries on angiography were analyzed. Patients were divided into 2 groups according to the presence of CSF based on thrombolysis in myocardial infarction (TIMI) frame count. Demographic, clinical, and laboratory parameters were compared between groups. Receiver operating characteristic (ROC) analysis was used to determine the discriminatory performance of UHR, and multiple logistic regression was performed to identify independent predictors of CSF. RESULTS: The mean UHR value was significantly higher in the CSF group compared with the control group (0.13 ± 0.04 vs. 0.09 ± 0.04, P 0.107 predicted CSF with moderate discriminatory ability (area under the curve (AUC) = 0.733, 95% CI: 0.66-0.79, P < .001), with 73.5% sensitivity and 76.2% specificity. Multiple analyses suggested that UHR was independently associated with CSF (OR 1.20 per 0.01-unit increase, 95% CI 1.09-1.31, P < .001). CONCLUSION: Elevated UHR was independently associated with CSF and may represent a readily available biomarker reflecting the metabolic-inflammatory balance contributing to coronary microvascular dysfunction. These findings should be interpreted as associative and hypothesis-generating.
Astan et al. (Thu,) conducted a cross-sectional in Coronary slow flow (n=218). Uric acid-to-high-density lipoprotein cholesterol ratio (UHR) vs. Control group (without coronary slow flow) was evaluated on Presence of coronary slow flow (OR 1.20 per 0.01-unit increase, 95% CI 1.09-1.31, p=< .001). Elevated uric acid-to-HDL cholesterol ratio was independently associated with coronary slow flow (OR 1.20 per 0.01-unit increase; 95% CI 1.09-1.31; P < .001).