Physiologically Based Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Analysis for Ceftriaxone Dosing in Pregnant Women: Model Development and Clinical Applications

Key Points

• This research aims to develop a pharmacokinetic and pharmacodynamic model for ceftriaxone dosing in pregnant women.
• Developed a modeling framework to quantify pharmacodynamic margins for ceftriaxone dosing.
• Analyzed dosing strategies under standard regimens of 1 g and 2 g.
• Evaluated implications for precision medicine in obstetric pharmacotherapy.
• Established breakpoint reduction from 2.81 to 1.75 µg/mL at 1 g q.d. dose.
• Reduced breakpoint from 5.61 to 3.50 µg/mL at 2 g q.d. dose.
• Highlighted the need for revising pregnancy dosing strategies based on pharmacodynamic analysis.