Purpose To analyze phytochemical composition, antioxidant potential, antimicrobial activity and α-glucosidase, cholinesterase and Monoamine oxidase inhibitory potential of Oxalis corniculata extract. Methods Phytochemicals of the 70% ethanolic extract of O. corniculata were quantitatively determined by standard spectrophotometric method. The anti-oxidative and antibacterial potential were investigated by DPPH scavenging test and by well-diffusion method respectively. The p-NPG technique was applied to evaluate α-glucosidase inhibition potential. Moreover, cholinesterase and Monoamine oxidase -A 154.83 ± 0.04 µg/mg and phenolic contents; 135.29 ± 0.01 µg/mg. DPPH radical scavenging of the extract indicates good IC 50 value 40.74 µg/ml according to the standard ascorbic acid; 25.79 µg/ml. The bacterial inhibition revealed that the extract were high inhibitory against E. coli, H. influenza and k. pneumonia while showing no inhibition against Acetobactor aceti . Similarly, Acetylcholinesterase and Butyrylcholinesterase inhibition result revealed that O. corniculata have effective anti-cholinesterase potential with the IC 50 value of Acetylcholinesterase; 34.54 µg/ml and Butyrylcholinesterase; 8.91 µg/ml. Moreover, O. corniculata has good potential against MAO-B inhibition with an IC 50 value; 60.68 µg/ml, while showing IC 50 value; 274.23 µg/ml against MAO-A. Furthermore, the inhibitory potential against α- glucosidase of the extract shows significant IC 50 value (40.59 µg/ml). Conclusion O. corniculata exhibits potential as a valuable reservoir of natural bioactive compounds endowed with a wide array of health-promoting properties.
Ullah et al. (Thu,) studied this question.