What question did this study set out to answer?

The study aims to explore the relationship between systemic inflammation, T cell responses, and hepatic energy metabolism in recent-onset type 1 diabetes.

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May 16, 2026Open Access

Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent‐Onset Type 1 Diabetes

Key Points

The study aims to explore the relationship between systemic inflammation, T cell responses, and hepatic energy metabolism in recent-onset type 1 diabetes.
Assessment of hepatic energy metabolism in lean individuals with early type 1 diabetes (N=...)
Measurement of inflammatory profiles and T cell responses
Registered under ClinicalTrial.gov identifier: NCT01055093.
Strong association between hepatic energy metabolism and specific inflammatory profiles observed (p<0.05)
T cell responses correlate with the regulation of hepatic metabolism
Pro-inflammatory mechanisms play a role despite the absence of steatotic liver disease.

Abstract

< 0.05). Even in lean metabolically well-controlled persons with early type 1 diabetes, measures of hepatic energy metabolism strongly associate with a specific inflammatory profile and T cell responses, suggesting a role of pro-inflammatory mechanisms in the regulation of hepatic metabolism, even in the absence of steatotic liver disease. Trial Registration: ClinicalTrial.gov identifier: NCT01055093.

Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent‐Onset Type 1 Diabetes

Key Points

Abstract

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