A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia

Xinmei Huang; Jaimie D Steinmetz; Elizabeth K. Marsh; Aleksandr Y. Aravkin; Charlie Ashbaugh; Christopher J L Murray; Fang Yang; John S. Ji; Peng Zheng; Reed J D Sorensen; Sarah Wozniak; Simon I Hay; Susan A. McLaughlin; Vanessa Garcia; Michael Bräuer; Katrin Burkart

doi:10.1038/s43587-025-00844-y

March 21, 2025Nature AgingOpen Access

A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia

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Key Points

This research aims to assess the health effects of long-term exposure to PM2.5 on dementia, particularly Alzheimer's disease.
Conducted a systematic review and Burden of Proof meta-analysis.
Included studies analyzing correlation between PM2.5 exposure and dementia types, specifically Alzheimer's and vascular dementia.
Found a significant association with Alzheimer's disease (n = 12, ROS = 0.32, three stars).
No observed correlation with vascular dementia.

Implication

Systematic review reveals links between PM2.5 exposure and Alzheimer's disease, suggesting air pollution impacts brain aging.

Abstract

with Alzheimer's disease (n = 12, ROS = 0.32, three stars) but not with vascular dementia. Our findings highlight the potential impact of air pollution on brain aging.

Discussion

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/6a081661df3db87398107991 https://doi.org/10.1038/s43587-025-00844-y

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A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia

Key Points

Implication

Abstract

Discussion

Cite This Study

A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia

Key Points

Implication

Abstract

Discussion

Cite This Study

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