Characterisation of the N ‐Methyltransferase Sg PsmC: Application in the Kinetic Resolution of Pyrroloindolines

Many natural products and pharmaceutical compounds bear the pyrroloindoline scaffold, highlighting the importance of the heterocyclic motif. Here, we aim at expanding the toolset for the selective synthesis of pyrroloindolines by characterising and employing the N-methyltransferase SgPsmC from Streptomyces griseofuscus, an enzyme involved in the biosynthesis of physostigmine, in a selective kinetic resolution of pyrroloindolines performed at a laboratory preparative scale.