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June 29, 2018Cold Spring Harbor Perspectives in Biology154 citationsOpen Access

Mechanistic Insights into MicroRNA-Mediated Gene Silencing

TDThomas F. DuchaîneMFMarc R. Fabian

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Abstract

MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger RNA (mRNA) translation and promoting mRNA decay.

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Duchaîne et al. (2018) studied this question.

synapsesocial.com/papers/6a082a43df3db87398107fadhttps://doi.org/10.1101/cshperspect.a032771
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