Comparison of mechanical and thermal effects of focused ultrasound on drug delivery efficiency and toxicity for pancreatic cancer treatment

and 1 % duty cycle enhanced drug accumulation to tumor by 1.57-fold without tissue damage. Also, FOLFIRINOX combined with mechanical effects achieved superior antitumor efficacy, with 83.0 % tumor inhibition compared to 48.0 % with FOLFIRINOX alone. And mechanical effect was validated as a non-toxic energy for tumor treatment by H&E, TUNEL assay and serum biochemistry analysis. In conclusion, FUS-mediated mechanical effects can be one of candidate as a safe and effective strategy for tumor-specific drug delivery.