Key result
Sildenafil suppresses PVCs and delays their onset by ~21 ms in a systemic sclerosis patient.
Why the study?
Although sildenafil suppresses ventricular arrhythmias in animal models, evidence for its anti-arrhythmic effects in humans with arrhythmias is lacking.
Does sildenafil suppress premature ventricular complexes in a human patient?
Population
One 50-year-old female with a history of PVCs and systemic sclerosis
Comparison
Sildenafil initiation vs baseline and washout
Design
Case study
Follow-up
7 days
Authors
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Hypothesis-generating for sildenafil anti-arrhythmic effects in systemic sclerosis; should not yet change practice.
Case Report (n=1)
Does sildenafil suppress premature ventricular complexes in a human patient?
This case report provides the first clinical evidence suggesting that sildenafil may have anti-arrhythmic properties in humans by suppressing premature ventricular complexes.
Hutchings et al. (2025) conducted a case report in Premature ventricular complexes and systemic sclerosis (n=1). Sildenafil vs. Baseline/Washout was evaluated on Frequency and timing of premature ventricular complexes. Sildenafil abolished late premature ventricular complexes and substantially reduced early ones, delaying their onset by 21 ms from the preceding T wave apex in a patient with systemic sclerosis.
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