Key result
Long-term treatment with captopril and a diuretic significantly lowered the rate of decline in glomerular filtration rate (5.8 vs 10.0 ml/year, p<0.01) in diabetics with nephropathy.
Why the study?
Does captopril combined with diuretics improve kidney function and reduce albuminuria in hypertensive insulin-dependent diabetics with nephropathy?
Observational (n=31)
No
Does captopril combined with diuretics improve kidney function and reduce albuminuria in hypertensive insulin-dependent diabetics with nephropathy?
Absolute Event Rate: 5.8% vs 10%
p-value: p=<0.01
Captopril combined with diuretics significantly reduces the rate of decline in glomerular filtration rate and decreases albuminuria in hypertensive insulin-dependent diabetics with nephropathy.
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Supports renoprotection hypothesis with captopril in diabetic nephropathy; leaves open need for randomized confirmation before practice change.
Parving et al. (1988) conducted an observational in Hypertensive insulin dependent diabetics with nephropathy (n=31). Captopril and frusemide or bendrofluazide vs. No treatment was evaluated on Rate of decrease in glomerular filtration rate (ml/year) (p=<0.01). Long-term treatment with captopril and a diuretic significantly lowered the rate of decline in glomerular filtration rate (5.8 vs 10.0 ml/year, p<0.01) in diabetics with nephropathy.
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