Key result
Autonomic dysfunction in octogenarians links to ~80% white matter disease incidence and high dementia risk.
Why the study?
The links between autonomic dysfunction, multiple brain diseases, and diabetes in older individuals remain obscure.
Autonomic dysfunction in older adults is highly prevalent and associated with multiple brain diseases and diabetes, requiring careful management to prevent syncope and other complications.
Answers are grounded in this paper and cite their sources.
May warrant autonomic evaluation in octogenarians with dementia or diabetes; leaves open causal links and prospective trials.
The present article reviewed autonomic dysfunction in older individuals. The following estimated incidences are reported among octogenarians (age >80 years): white matter disease (WMD), 80%; Alzheimer's disease (AD), 33%; and dementia with Lewy bodies (DLB), 7%–8%. A combination of AD + WMD is the most common. The estimated incidence in octogenarians of diabetes that produces small fiber neuropathy is 30%. Orthostatic hypotension, overactive bladder, and bowel motility dysfunction also increase with age. The links between all of these disorders are still obscure, but associations have been postulated between orthostatic hypotension with DLB and diabetes, between overactive bladder with WMD and DLB (AD in part), and between bowel motility dysfunction with DLB and diabetes. Management and care of autonomic dysfunction is thus necessary to maximize the quality of life of older individuals and avoid emergency of syncope, urinary retention, or ileus.
No takes yet. Share an insight, caveat, or question.
Sakakibara et al. (2022) conducted a review in Autonomic dysfunction. Autonomic dysfunction in octogenarians is associated with high estimated incidences of white matter disease (80%), Alzheimer's disease (33%), dementia with Lewy bodies (7-8%), and diabetes (30%).
Synapse has enriched 10 related papers. Consider them for comparative context: