Why the study?
Limited data exist on the impact of asthma on long QT syndrome in middle-aged and older adults.
Does the presence of asthma increase the risk of cardiac events in patients with long QT syndrome over age 40?
Population
1020 LQTS patients from the Rochester LQTS Registry
Comparison
Presence of asthma with and without β2-agonist inhaler treatment
Design
Registry-based study
Follow-up
From age 40 through 75 years
Key result
The presence of asthma is associated with an increased risk of cardiac events among middle-aged and older patients with long QT syndrome, regardless of β2-agonist inhaler treatment.
Authors
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Asthma signals higher cardiac event risk in LQTS patients over 40; leaves open whether it refines risk models or warrants practice changes.
Cohort (n=1,020)
Does the presence of asthma increase the risk of cardiac events in patients with long QT syndrome over age 40?
p-value: p== .963
Asthma is associated with an increased risk of cardiac events in middle-aged and older patients with long QT syndrome, independent of β2-agonist inhaler use.
Barsheshet et al. (2024) conducted a cohort in Long QT syndrome (n=1,020). Asthma (with or without β2-agonist inhaler) vs. No asthma was evaluated on Cardiac events (syncope, aborted cardiac arrest, implantable cardioverter-defibrillator shock, or sudden cardiac death) (p== .963). The presence of asthma is associated with an increased risk of cardiac events among middle-aged and older patients with long QT syndrome, regardless of β2-agonist inhaler treatment.