Key result
In adolescents with long-QT syndrome, having 1 syncopal episode in the last 2 years strongly predicted aborted cardiac arrest or sudden cardiac death (HR 11.7; 95% CI 7.0-19.5; P<.001).
Population
2,772 participants with clinically suspected long-QT syndrome alive at age 10 years, multinational.
Design
Cohort
Follow-up
up to 10 years (from age 10 to 20 years)
Authors
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Recent syncope identifies high-risk LQTS adolescents; extends risk stratification but leaves practice change open pending trials.
Cohort (n=2,772)
Yes
Effect estimate: HR 11.7 (95% CI 7.0-19.5)
p-value: p=<.001
In adolescents with long-QT syndrome, recent syncope, QTc prolongation, and male sex (ages 10-12) are strong predictors of aborted cardiac arrest or sudden cardiac death, and beta-blockers significantly reduce this risk in those with recent syncope.
Hobbs et al. (2006) conducted a cohort in Hereditary long-QT syndrome (LQTS) (n=2,772). Recent syncope (1 episode in the last 2 years) vs. No syncopal events in the last 10 years was evaluated on Aborted cardiac arrest or LQTS-related sudden cardiac death (HR 11.7, 95% CI 7.0-19.5, p=<.001). In adolescents with long-QT syndrome, having 1 syncopal episode in the last 2 years strongly predicted aborted cardiac arrest or sudden cardiac death (HR 11.7; 95% CI 7.0-19.5; P<.001).
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