Key points are not available for this paper at this time.
Abstract The sequenced Diels–Alder/oxidation reaction represents a powerful route for the construction of aromatic compounds in organic synthesis. The oxidative Diels–Alder reaction with H 2 evolution would be a more ideal approach that can avoid the additional oxidation procedure and stoichiometric oxidant. Herein, an oxidative 4 + 2 annulation reaction of styrene derivatives with electron-rich dienophiles accompanying the H 2 generation has been developed by using the synergistic merger of photoredox and cobaloxime catalyst. With respect to atom and step-economy ideals, this dual catalytic system enables the formation of high-value molecules from feedstock chemicals in a single step under room temperature.
Zhang et al. (Mon,) studied this question.