Precise Distal B–H Bond Activation of nido-Carboranes by Copper Catalysis: Synthesis of Benzene Bioisosteres from Boron Clusters

-carboranes. The current protocol enables the synthesis of a series of multifunctionalized boron cluster derivatives for the construction of benzene bioisosteres. The reaction proceeds under mild conditions with rapid conversion and exhibits a broad substrate scope and excellent group tolerance. These features render the method highly adaptable for the development of boron-cluster-modified pharmaceuticals and trinity-type boron neutron capture therapy (BNCT) drug candidates. Additionally, high-performance carborane-based luminogens, which were facilely constructed by the developed reaction, exhibit multicolor emissions, high solid-state luminescence efficiency, and aggregation-induced circularly polarized luminescence (AI-CPL). This study not only demonstrates the potential of boron clusters as benzene mimetics but also opens new avenues for drug discovery and materials development.