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-carboranes. The current protocol enables the synthesis of a series of multifunctionalized boron cluster derivatives for the construction of benzene bioisosteres. The reaction proceeds under mild conditions with rapid conversion and exhibits a broad substrate scope and excellent group tolerance. These features render the method highly adaptable for the development of boron-cluster-modified pharmaceuticals and trinity-type boron neutron capture therapy (BNCT) drug candidates. Additionally, high-performance carborane-based luminogens, which were facilely constructed by the developed reaction, exhibit multicolor emissions, high solid-state luminescence efficiency, and aggregation-induced circularly polarized luminescence (AI-CPL). This study not only demonstrates the potential of boron clusters as benzene mimetics but also opens new avenues for drug discovery and materials development.
Zhou et al. (Fri,) studied this question.