May 26, 2004

Cobalt(I)‐Catalyzed Asymmetric 2+2+2 Cycloaddition of Alkynes and Nitriles: Synthesis of Enantiomerically Enriched Atropoisomers of 2‐Arylpyridines

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Abstract

A new flavor of chiral induction in the 2+2+2 cycloaddition yielding pyridines: Atropoisomers were prepared in the reaction of alkynes and nitriles in the presence of 1 mol % chiral CoI catalysts such as 1 with high yields and up to 93 % ee.

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Gutnov et al. (Wed,) studied this question.

synapsesocial.com/papers/6a0867d4113ba5b476de2402 https://doi.org/https://doi.org/10.1002/anie.200454164

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