Key result
Herbal plant extracts show potential to reverse cardiac fibrosis by modulating inflammation and oxidative stress.
Why the study?
Cardiac fibrosis contributes to cardiac function decline across multiple heart diseases, prompting interest in herbal plants and their extracts as potential therapeutics.
Do herbal plants and their extracts reverse cardiac fibrosis?
Do herbal plants and their extracts reverse cardiac fibrosis?
Herbal plants and their extracts represent a promising therapeutic approach for reversing cardiac fibrosis.
Should not yet alter clinical management of cardiac fibrosis; hypothesis-generating for herbal therapies pending prospective trials.
Cardiac fibrosis is closely associated with multiple heart diseases, which are a prominent health issue in the global world. Neurohormones and cytokines play indispensable roles in cardiac fibrosis. Many signaling pathways participate in cardiac fibrosis as well. Cardiac fibrosis is due to impaired degradation of collagen and impaired fibroblast activation, and collagen accumulation results in increasing heart stiffness and inharmonious activity, leading to structure alterations and finally cardiac function decline. Herbal plants have been applied in traditional medicines for thousands of years. Because of their naturality, they have attracted much attention for use in resisting cardiac fibrosis in recent years. This review sheds light on several extracts from herbal plants, which are promising therapeutics for reversing cardiac fibrosis.
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Xuejing Yu (2023) conducted a review in Cardiac fibrosis. Herbal plant extracts was evaluated. Herbal plant extracts demonstrate promising therapeutic potential for reversing cardiac fibrosis by modulating multiple signaling pathways, inflammation, and oxidative stress.
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