Key result
The TSP-4 A387P polymorphism was not associated with an altered risk of CAD (P=0.51), MI (P=0.13), or premature MI (P=0.17) in the Chinese Han population.
Why the study?
Is the TSP-4 A387P polymorphism associated with an increased risk of CAD or MI in the Chinese Han population?
Population
1,664 individuals from the Chinese Han population, comprising 817 patients with angiographically verified…
Comparison
Presence of the TSP-4 A387P polymorphism vs Absence of the TSP-4 A387P polymorphism
Design
Case-control
Authors
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No association in Chinese Han; leaves open ethnic differences in TSP-4 A387P and CAD susceptibility.
Case-Control (n=1,664)
Is the TSP-4 A387P polymorphism associated with an increased risk of CAD or MI in the Chinese Han population?
p-value: P (CAD)=0.51, P (MI)=0.13, P (Premature MI)=0.17
The TSP-4 A387P polymorphism is not associated with an increased risk of CAD or MI in the Chinese Han population, contrasting with its higher prevalence and potential role in Western populations.
Zhou et al. (2004) conducted a case-control in Coronary artery disease and myocardial infarction (n=1,664). TSP-4 A387P polymorphism vs. Healthy controls (or GG genotype) was evaluated on Risk of CAD, MI, or premature MI (p=P (CAD)=0.51, P (MI)=0.13, P (Premature MI)=0.17). The TSP-4 A387P polymorphism was not associated with an altered risk of CAD (P=0.51), MI (P=0.13), or premature MI (P=0.17) in the Chinese Han population.
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