Why the study?
Women appear to respond differently to CRT, but it remains unclear whether this is inherent to female sex or driven by other patient characteristics.
Does sex determine reverse LV remodelling response to CRT in patients with HFrEF?
Does sex determine reverse LV remodelling response to CRT in patients with HFrEF?
Non-ischemic etiology, rather than female sex itself, is responsible for the greater reverse LV remodelling response rates observed in women treated with CRT.
Answers are grounded in this paper and cite their sources.
Adjusting for etiology eliminates apparent sex differences in CRT response; leaves open independent sex effects in prospective HFrEF studies.
INTRODUCTION: Cardiac resynchronization therapy (CRT) is an established therapy for patients with heart failure with reduced ejection fraction (HFrEF). Women appear to respond differently to CRT, yet it remains unclear whether this is inherent to the female sex itself, or due to other patient characteristics. In this study, we aimed to investigate sex differences in response to CRT. METHODS: = 818). RESULTS: > 0.05 for all). Results were comparable in the Belgian cohort. CONCLUSIONS: Women showed a greater echocardiographic response to CRT at 6 months follow-up. However, after adjustment for BSA and ischemic etiology, no differences were found in LV-function measures or survival, suggesting that non-ischemic etiology is responsible for greater response rates in women treated with CRT.
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Said et al. (2021) studied this question.
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