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ABSTRACT 1,4‐Diyn‐3‐ones and 1,4‐diyn‐3‐ols have garnered considerable attention due to their distinctive characteristics, including multiple reaction sites. Numerous new reactions involving these compounds have been discovered in the past decades. Their transformations can provide a variety of useful O‐containing and N‐containing heterocycles with high regio‐ and stereoselectivity, including pyrones, pyrrolones, furans, and pyridones. In this review, we summarize the latest trends and developments of reactions involving 1,4‐diyn‐3‐ones and 1,4‐diyn‐3‐ols with a series of reagents including amines, water, N ‐oxides, 1,3‐dicarbonyl compounds, quinolines, isoxazoles, and so on. We highlight the product diversity, selectivity, and applicability of these transformations and, where possible, discuss the underlying mechanistic rationale.
Wang et al. (Sat,) studied this question.