PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 1, 2025New Journal of Chemistry14 citations

Mechanistic insights into the regio- and stereoselectivity of 3+2 cycloaddition reactions between N-methyl-phenylnitrone and trans-1-chloro-2-nitroethylene within the framework of molecular electron density theory

View Full Paper
SBSofiane BenmetirMCMohamed ChelleguiLBLakhdar Benhamed

Key Points

Key points are not available for this paper at this time.

Abstract

The 3+2 cycloaddition of N -methyl-phenylnitrone and trans -1-chloro-2-nitroethylene reveals high ortho regioselectivity and endo stereoselectivity, supported by MEDT and molecular docking studies, suggesting potential for colorectal cancer therapy.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Benmetir et al. (2025) studied this question.

synapsesocial.com/papers/6a086bda1e0fcf4a43e8c35ehttps://doi.org/10.1039/d5nj01419k
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism and stereoselectivity of a [3 + 2] cycloaddition involving a glucosyl nitrone: a MEDT study2025 · 17 citations
  2. 2A MEDT computational study of the mechanism, reactivity and selectivity of non-polar [3+2] cycloaddition between quinazoline-3-oxide and methyl 3-methoxyacrylate2020 · 17 citations
  3. 3Synthesis and pharmacological assessment of derivatives of isoxazolo[4,5-d]pyrimidine2003 · 59 citations
  4. 4Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms2007 · 1,061 citations
  5. 5The path of chemical reactions - the IRC approach1981 · 6,656 citations