The antiangiogenic and cytotoxic natural product pseudolaric acid A ((−)-1) has been obtained by a 26-step synthetic route. This enantioselective synthesis employed an intramolecular carbene cyclization cycloaddition cascade reaction as the key step to construct the carbocyclic framework. PMB=para-methoxybenzyl.
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Geng et al. (2006) studied this question.
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