Total Synthesis of Fostriecin (CI-920)

The most selective protein phosphatase inhibitor identified to date, fostriecin was synthesized in a highly convergent manner by a chiral building block approach (see picture). Three of the four stereocenters were introduced by using catalytic methods, including novel and practical applications of asymmetric hetero-Diels–Alder (HDA) and hydrolytic kinetic resolution reactions. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2001/z17535ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.