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Explores Pd@Pt nanoparticles' effects on glucose metabolism in diabetes, suggesting new treatment options.
Summary Pd@Pt nanozymes are recognized for their extensive specific surface area and enzyme-like catalytic capabilities. However, the role of Pd@Pt nanoparticles in managing metabolic disorders such as diabetes and its related disorders remains poorly understood. This study endeavors to explore the regulatory function of Pd@Pt nanoparticles in metabolic balance, elucidating the associated mechanisms. We demonstrate that Pd@Pt inhibits the production of reactive oxygen species and modulates oxidative stress through its superoxide-dismutase-like enzyme activity in palmitic-acid-induced insulin resistance cell model. Furthermore, Pd@Pt was found to enhance glucose uptake, reduce hyperglycemia, and improve glucose tolerance and insulin sensitivity, attributable to its anti-inflammatory effects. Additionally, the effectiveness of the multifunctional Pd@Pt-based microneedle in expediting the healing of diabetic wounds was confirmed by suppressing key inflammatory signaling pathways. Collectively, our findings highlight the potential of Pd@Pt nanoparticles as powerful anti-inflammatory agents, offering promising therapeutic options for type 2 diabetes and its associated complications.
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Wang et al. (2025) studied this question.
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