The Chemical Synthesis of Bioactive Glycosylphosphatidylinositols from Trypanosoma cruzi Containing an Unsaturated Fatty Acid in the Lipid

Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R=(CH2)7CHCH(CH2)7CH3, and 2, R=(CH2)7CHCHCH2CHCH(CH2)4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z502779_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.