US-SWEI identified changes in diaphragm viscoelastic properties driven by fibrosis in mdx mice (P=0.025), establishing it as a feasible approach for monitoring respiratory muscle health.
Can US-SWEI noninvasively assess early-stage changes in diaphragm viscoelastic properties in mdx mice?
US-SWEI is a feasible noninvasive imaging approach for monitoring early-stage diaphragm changes in preclinical models of Duchenne muscular dystrophy.
p-value: p=0.025
=0.54,P=0.025), supporting fibrosis as a primary factor driving changes in diaphragm viscoelastic properties. These findings establish US-SWEI as a noninvasive, feasible approach for monitoring respiratory muscle health and advancing preclinical DMD research. By identifying early-stage changes in diaphragm properties, this approach enables the development of therapeutic interventions targeting respiratory complications. Furthermore, US-SWEI presents a potential avenue for assessing and monitoring neuromuscular diseases.
Lee et al. (Thu,) conducted a other in Duchenne muscular dystrophy. US-SWEI was evaluated on diaphragm viscoelastic properties (p=0.025). US-SWEI identified changes in diaphragm viscoelastic properties driven by fibrosis in mdx mice (P=0.025), establishing it as a feasible approach for monitoring respiratory muscle health.