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May 20, 1971New England Journal of Medicine204 citations

Influence of Aortocoronary Bypass Surgery on Left Ventricular Performance

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GRGareth ReesCardiff UniversityJBJames BristowThe Christie NHS Foundation TrustEKE. Louise KremkauOregon Health & Science University

Key Result

Aortocoronary-vein-bypass surgery improved left ventricular function in 8 patients with successful grafts, whereas function deteriorated in 6 patients with graft occlusion.

Study Design

Type

Observational (n=14)

Structured PICO

Does aortocoronary bypass surgery improve left ventricular performance in patients with angina pectoris?

P
Population
14 selected patients with angina pectoris undergoing aortocoronary-vein-bypass operations
I
Intervention
Aortocoronary-vein-bypass operation
C
Comparator
Pre-operative baseline (and comparison between anatomically successful vs unsatisfactory results)
O
Outcome
Left ventricular performance measured by quantitative analysis of left ventricular cineangiocardiograms (end-systolic volume, ejection fraction, rate of circumferential fiber shortening)surrogate

Successful aortocoronary bypass surgery improves left ventricular function, whereas graft occlusion leads to functional deterioration.

Abstract

Abstract Quantitative analysis of left ventricular cineangiocardiograms was performed before and after aortocoronary-vein-bypass operations for angina pectoris in 14 selected patients. Eight patients with anatomically successful results had a decrease in left ventricular end-systolic volume, and an increase in ejection fraction and the rate of circumferential fiber shortening at the ventricular equator. In two, improvement in the motion of akinetic regions of the ventricular wall was found. Six other patients had anatomically unsatisfactory results, usually because of occlusion of the graft. Ejection fraction and fiber-shortening rate fell in these, and the end-systolic volume was higher after operation. End-diastolic volume was similar in both groups and was not consistently altered by operation. In patients without severe depression of ventricular performance, ventricular function improved when the operation was technically successful. Deterioration of function accompanied graft occlusion.

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Cite This Study

Rees et al. (1971) conducted an observational in Angina pectoris (n=14). Aortocoronary-vein-bypass operation vs. Pre-operative baseline / Unsuccessful graft was evaluated on Left ventricular performance (end-systolic volume, ejection fraction, rate of circumferential fiber shortening). Aortocoronary-vein-bypass surgery improved left ventricular function in 8 patients with successful grafts, whereas function deteriorated in 6 patients with graft occlusion.

synapsesocial.com/papers/6a0874e11e8b9db648de0cc7https://doi.org/10.1056/nejm197105202842002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systolic and Diastolic Abnormalities of the Left Ventricle in Coronary Artery Disease1970 · 166 citations
  2. 2Left Ventricular Chamber Volume, Mass, and Function in Severe Coronary Artery Disease1970 · 59 citations
  3. 3A Hemodynamic Study of Left Ventricular Aneurysm1967 · 299 citations
  4. 4Left Ventricular Pressure-Volume Alterations and Regional Disorders of Contraction During Myocardial Ischemia Induced by Atrial Pacing1970 · 259 citations
  5. 5The Role of Left Atrial Transport in Aortic and Mitral Stenosis1970 · 119 citations