Why the study?
The study sought to evaluate the clinical efficacy of third-generation laser balloon ablation using an anatomical-based approach without verifying electrical isolation.
Does anatomical-guided third-generation laser balloon ablation prevent atrial tachyarrhythmia recurrence in patients with paroxysmal atrial fibrillation?
Does anatomical-guided third-generation laser balloon ablation prevent atrial tachyarrhythmia recurrence in patients with paroxysmal atrial fibrillation?
Anatomical-guided third-generation laser balloon ablation without electrical verification provides high rates of freedom from atrial tachyarrhythmia over 3 years in patients with paroxysmal atrial fibrillation.
Provides 3-year outcome data for anatomical-guided laser balloon ablation in paroxysmal AF; leaves open need for randomized comparisons.
AIMS: The third-generation laser balloon (LB3) is an established ablation device for pulmonary vein isolation (PVI) that allows direct visualization of the anatomical target. Equipped with an automatic circumferential laser delivery modality, it aims at continuous circumferential PVI, improving both acute and clinical outcomes. We sought to evaluate the clinical efficacy of LB3 ablation using an anatomical-based approach without verifying electrical isolation. METHODS AND RESULTS: Among 257 paroxysmal AF patients undergoing LB3 ablation across four Italian centres, 204 (72% male, mean age 60.4 ± 11.1 years) were included. The primary endpoint was freedom from any atrial tachyarrhythmia (ATa) recurrence after the blanking period (BP), assessed with implantable cardiac monitors (ICMs). All pulmonary veins (PVs) were targeted using the LB3, with the RAPID mode used on an average of 96 ± 8, 86 ± 19, 98 ± 11, and 84 ± 15% for the left superior, left inferior, right superior, right inferior PV, and left common ostium, respectively. Freedom from arrhythmia recurrences was 84.8% at 1, 80.4% at 2, and 76.0% at 3 years. An ATa burden ≥ 5% was documented in 2.5, 4.4, and 5.4% at 1, 2, and 3 years, respectively. Relapses during the BP [hazard ratio (HR) = 2.182, P = 0.032] and left atrial dilation (HR = 1.964, P = 0.048) were independent predictors of recurrences. CONCLUSION: Anatomical-guided LB3 ablation for paroxysmal AF is a safe and effective approach, providing excellent clinical outcomes as assessed by ICM over nearly 3 years of follow-up.
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Ciconte et al. (2024) studied this question.
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