Key result
Adding contractile stress transverse to the muscle fiber in finite-element models improved myocardial strain agreement with experimental measurements by 27% (RMS error 0.054 vs 0.074, P<0.05).
Population
5 sheep with anteroapical myocardial infarction (25% of LV mass) 22 weeks prior
Comparison
Tagged MRI and finite-element modeling… vs FE analysis with only uniaxial contracting stress
Design
Preclinical
Follow-up
22 weeks post-MI
Authors
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Supports transverse contractile stress in post-MI LV FE models; leaves open human validation.
Absolute Event Rate: 0.054% vs 0.074%
p-value: p=<0.05
Active cross-fiber stress development is an integral part of LV systole, and its inclusion in finite-element models significantly improves the accuracy of myocardial strain predictions in LV aneurysms.
Walker et al. (2005) studied Left ventricular aneurysm post-myocardial infarction (n=5). Finite-element models including transverse contractile stress vs. Finite-element models with only uniaxial contracting stress was evaluated on Myocardial strain agreement (RMS error) between FE model predictions and experimental measurements (p=<0.05). Adding contractile stress transverse to the muscle fiber in finite-element models improved myocardial strain agreement with experimental measurements by 27% (RMS error 0.054 vs 0.074, P<0.05).
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