Key result
Cardiac immune cells directly drive the onset and progression of atrial and ventricular arrhythmias.
Why the study?
Cardiac arrhythmias are a major cause of morbidity and mortality, with emerging evidence indicating resident and infiltrating cardiac immune cells play direct mechanistic roles in arrhythmia onset and progression.
This review summarizes the emerging mechanistic roles of various immune cell subtypes in the pathogenesis of atrial and ventricular arrhythmias.
Supports immune-targeted arrhythmia research; leaves open clinical translation and outcomes data.
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide. Emerging evidence has demonstrated that resident and infiltrating cardiac immune cells play direct, mechanistic roles in arrhythmia onset and progression. In this review, we provide a comprehensive summary and expert commentary on the role of each immune cell subtype in the pathogenesis of atrial and ventricular arrhythmias.
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Keefe et al. (2025) conducted a review in Cardiac arrhythmias. Resident and infiltrating cardiac immune cells play direct, mechanistic roles in the onset and progression of atrial and ventricular arrhythmias.
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