Retrospective study identifies key risk factors for subsequent spinal fractures in postmenopausal women treated with cement augmentation, highlighting the need for targeted bone preservation.
Background: Subsequent vertebral fracture (SVF) as a severe complication of percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) for the treatment of osteoporotic vertebral compression fracture (OVCF) is a major public health challenge. Risk factors of SVF following initial PVP or PKP surgery in postmenopausal women are still controversial. This study aims to investigate the risk factors of SVF after initial PVP or PKP for single-level OVCF in postmenopausal women. Methods: Postmenopausal women who were initially treated with PVP or PKP for single-level OVCF were retrospectively analyzed. The patients were divided into SVF group and control group based on whether they had SVF or not. Demographic, surgery-related and radiographic data were recorded from electronic medical records or radiographic examinations. Univariate and multivariate logistic regression analysis were conducted to determine the independent risk factors. Conclusions: Low BMI, previous vertebral fracture history and low BMD were independent risk factors of SVF in postmenopausal women treated with initial PVP or PKP for single-level OVCF.
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