Why the study?
Primary prevention of SCD in Brugada syndrome is recognized, but ventricular arrhythmia risk stratification remains challenging and controversial.
Is the type of syncope associated with major arrhythmic events in patients with Brugada syndrome?
Is the type of syncope associated with major arrhythmic events in patients with Brugada syndrome?
In patients with Brugada syndrome, cardiac and unexplained syncope are markers of increased risk for major arrhythmic events, highlighting their importance in risk stratification.
Answers are grounded in this paper and cite their sources.
Supports syncope subtype differentiation for MAE risk stratification in Brugada syndrome; extends pooled observational evidence but leaves prospective validation open.
Introduction: Brugada syndrome is an inherited arrhythmic disease associated with major arrhythmic events (MAE). The importance of primary prevention of sudden cardiac death (SCD) in Brugada syndrome is well recognized; however, ventricular arrhythmia risk stratification remains challenging and controversial. We aimed to assess the association of type of syncope with MAE via systematic review and meta-analysis. Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to December 2021. Included studies were cohort (prospective or retrospective) studies that reported the types of syncope (cardiac, unexplained, vasovagal, and undifferentiated) and MAE. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Results: = 64.6%, respectively) were not. Conclusion: Our study demonstrated that cardiac and unexplained syncope was associated with MAE risk in Brugada syndrome populations but not in vasovagal syncope and undifferentiated syncope. Unexplained syncope is associated with a similar increased risk of MAE compared to cardiac syncope.
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Rattanawong et al. (2023) studied this question.
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