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March 1, 1982Biometrics358 citations

Nomograms for Calculating the Number of Patients Needed for a Clinical Trial with Survival as an Endpoint

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DSDavid SchoenfeldJRJane R. Richter

Key Points

  • This research aims to develop nomograms to determine the sample size for clinical trials focused on survival outcomes.
  • Developed nomograms based on survival data with an exponential distribution.
  • Adjusted calculations for consistent patient entry into the trial.
  • Nomograms provide precise sample size estimations for survival analysis.
  • Valid for studies where patient survival follows an exponential distribution.

Abstract

This paper presents nomograms for calculating the sample size for a clinical trial with survival as an endpoint. The nomograms are valid when survival is exponential and patients enter the study uniformly.

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Cite This Study

Schoenfeld et al. (1982) studied this question.

synapsesocial.com/papers/6a0889afad370a6b44de2a2chttps://doi.org/10.2307/2530299
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