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Ahead! Epothilone B (1, RMe) displayed better antitumor activity than paclitaxel (Taxol), as shown by in vivo studies with resistant mouse tumor models. The "acyl sector" C1C8 in the epothilones is very sensitive to modification. The other two sectors (see structure on the right) can be varied to a certain extent; however, none of the analogues examined thus far have surpassed the parent compound.
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Su et al. (1997) studied this question.
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