Why the study?
Hyperglycemia-induced cardiac fibrosis is a key feature of diabetic cardiomyopathy, but the role of miR-150-5p in mediating cardiac inflammation and fibrosis in cardiac fibroblasts remained to be investigated.
Does miR-150-5p inhibition alleviate cardiac inflammation and fibrosis in high glucose-treated cardiac fibroblasts?
Population
Cardiac fibroblasts exposed to high glucose
Comparison
miR-150-5p knockdown vs miR-150-5p overexpression
Design
In vitro laboratory study
Authors
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Should not change practice in diabetic cardiomyopathy; hypothesis-generating for miR-150-5p inhibition in cardiac fibroblasts.
Does miR-150-5p inhibition alleviate cardiac inflammation and fibrosis in high glucose-treated cardiac fibroblasts?
Inhibition of miR-150-5p ameliorates high glucose-induced cardiac inflammation and fibrosis in cardiac fibroblasts by targeting Smad7, suggesting a potential therapeutic target for diabetic cardiomyopathy.
Che et al. (2019) studied this question.