Key result
Mast cell stabilization or renin inhibition markedly reduced active renin overflow, attenuated norepinephrine release, and decreased the incidence of reperfusion arrhythmias from 100% to 0-50% in isolated animal hearts.
Why the study?
Does mast cell stabilization or renin inhibition prevent arrhythmias and norepinephrine release in ischemia/reperfusion models?
Does mast cell stabilization or renin inhibition prevent arrhythmias and norepinephrine release in ischemia/reperfusion models?
p-value: p=<0.05
Mast cell-derived renin plays a pivotal role in activating a local cardiac renin-angiotensin system that leads to excessive norepinephrine release and arrhythmias during ischemia/reperfusion.
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Hypothesis-generating for mast cell stabilization in reperfusion injury; requires human validation before clinical consideration.
Christina J. Mackins (2006) studied Myocardial ischemia/reperfusion arrhythmias. Mast cell stabilizers (cromolyn, lodoxamide) or renin inhibitor (BILA2157) vs. Untreated control was evaluated on Incidence and duration of reperfusion arrhythmias (VT/VF) (p=<0.05). Mast cell stabilization or renin inhibition markedly reduced active renin overflow, attenuated norepinephrine release, and decreased the incidence of reperfusion arrhythmias from 100% to 0-50% in isolated animal hearts.
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