The global disease burden of ischemic stroke attributable to high body-mass index continuously increased from 1990 to 2021 and is projected to escalate until 2050.
Observational
Yes
The global burden of ischemic stroke attributable to high BMI has steadily increased since 1990 and is projected to continue rising through 2050, highlighting the need for targeted weight loss and stroke screening interventions.
Purpose: This study assessed the global burden, trends, and socioeconomic disparities of ischemic stroke attributable to high body-mass index (IS-HBMI) from 1990 to 2021, and to project future trends to 2050. Methods: Data were extracted from the Global Burden of Disease Study 2021 (GBD 2021; data accessed on November 8, 2025). The analysis focused on ischemic stroke attributable to high body-mass index, measuring deaths, disability-adjusted life years (DALYs), and their corresponding age-standardized rates (ASMR and ASDR) across all ages, both sexes, and all Socio-demographic Index (SDI) regions. Temporal trends were analyzed using Joinpoint regression (estimated annual percentage change, EAPC), and drivers of mortality change were quantified via demographic decomposition. A Bayesian age-period-cohort (BAPC) model projected future burden to 2050. Regional performance was benchmarked using a best-performance frontier analysis. Conclusion: The study revealed that the global disease burden of IS-HBMI had continuously increased from 1990 to 2021, and it was predicted to escalate until 2050. The findings emphasize the need for more detailed IS screening and weight loss measures tailored to specific regions and populations, which would benefit efforts to curb the projected rise in IS-HBMI deaths.
Ni et al. (Wed,) conducted a observational in Ischemic stroke attributable to high body-mass index. High body-mass index was evaluated on Deaths, disability-adjusted life years (DALYs), and their corresponding age-standardized rates. The global disease burden of ischemic stroke attributable to high body-mass index continuously increased from 1990 to 2021 and is projected to escalate until 2050.