Key result
Small for gestational age birth is linked to a 0.07 L/min reduction in exercise oxygen uptake.
Why the study?
Small for gestational age is linked to adult cardiovascular risk, but whether and how cardiac remodeling and dysfunction persist from childhood into adolescence is uncertain.
Does being born small for gestational age alter resting cardiovascular morphology and reduce exercise tolerance in adolescence compared to normal birth weight controls?
Cohort (n=58)
Single-blind
No
Does being born small for gestational age alter resting cardiovascular morphology and reduce exercise tolerance in adolescence compared to normal birth weight controls?
Effect estimate: Difference -0.07 L/min (95% CI -0.13 to -0.005)
p-value: p=0.035
Adolescents born small for gestational age exhibit reduced exercise tolerance and altered cardiopulmonary response to exercise, despite apparent normalization of resting cardiac structure and function.
May signal subclinical exercise impairment in SGA adolescents; leaves open need for prospective outcome studies before clinical action.
Background Being born small for gestational age (SGA) affects 7%–10% of newborns and is associated with increased cardiovascular risk and reduced exercise capacity in adulthood with unclear underlying mechanisms. Cardiac remodeling and dysfunction occur in fetuses and children born SGA, but it is uncertain whether and how these changes persist into adolescence. The aim of the study was to assess resting cardiovascular morphology and function together with exercise tolerance in adolescents born SGA. Methods A perinatal cohort of 30 adolescents born SGA (defined as birth weight below the 10th centile) and 28 normal birth weight controls in a tertiary university hospital in Spain was included. Participants were followed from preadolescence (age 7–12 years) into adolescence (age 12–17 years) with echocardiography and incremental cardiopulmonary exercise test (CPET). Results Although signs of cardiac remodeling and dysfunction were evident in SGA preadolescents, no significant differences in left ventricular dimensions and deformation could be demonstrated in SGA adolescents. During the follow-up period, the SGA cohort had a significantly higher increase in left ventricular (LV) base-to-apex length (SGA mean 17.61 ± 6.78 vs. controls 13.44 ± 5.12; p = 0.011), resulting in different change of LV sphericity (−0.07 ± 0.11 vs. −0.17 ± 0.14; p = 0.010). Significant differences could be observed in SGA during exercise with reduced oxygen uptake [ −0.07 L/min (−0.13 to −0.005); p = 0.035], expired carbon dioxide [−0.08 L/min (−0.15 to −0.01); p = 0.033], and peak expiratory flow rate [−0.11 L/s (−0.21 to −0.01); p = 0.029]. Conclusion Changes in cardiac shape and function, described in children born SGA, seem to be ameliorated in adolescence related to compensatory growth as compared to healthy controls. However, SGA adolescents had markedly reduced exercise tolerance.
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Novoa et al. (2025) conducted a cohort in Small for gestational age (SGA) (n=58). Small for gestational age (SGA) vs. Normal birth weight controls was evaluated on Oxygen uptake during exercise (Difference -0.07 L/min, 95% CI -0.13 to -0.005, p=0.035). Adolescents born small for gestational age exhibited significantly reduced exercise tolerance, including a 0.07 L/min reduction in oxygen uptake during exercise compared to healthy controls.
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