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Observational analysis reveals high LPP levels correlate with reduced chemoimmunotherapy efficacy in gastric cancer, indicating LPP serves as a viable biomarker and drug target.
memory T cell infiltration and tumor growth. High-LPP patients yielded fewer benefits from chemotherapy or immunotherapy, compared with the low-LPP group. We finally identified 28 compounds as sensitive drugs for high-LPP patients. Our findings suggested LPP might be a biomarker for treatment response and therapeutic target in gastric cancer.
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Wang et al. (2022) studied this question.
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