Key result
In the isolated C57/BL6 mouse heart, energy was produced by oxidation of long-chain fatty acids (18%), and isoproterenol decreased de novo triglyceride synthesis while increasing fatty acid oxidation.
Population
isolated C57/BL6 mouse heart
Design
Preclinical
Authors
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Highlights metabolic effects of isoproterenol in isolated mouse hearts; leaves open translation to human disease.
This study demonstrates the utility of NMR spectroscopy in quantifying myocardial substrate utilization and shows that isoproterenol shifts metabolism towards increased fatty acid oxidation and decreased de novo triglyceride synthesis.
Stowe et al. (2006) studied isolated C57/BL6 mouse heart. Isoproterenol was evaluated on Triglyceride turnover and rate of fatty acid oxidation. In the isolated C57/BL6 mouse heart, energy was produced by oxidation of long-chain fatty acids (18%), and isoproterenol decreased de novo triglyceride synthesis while increasing fatty acid oxidation.
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